منابع مشابه
Nucleophiles of High Reactivity in Phosphoryl Transfer Reactions: a-Effect Compounds and Fluoride Ion'
The second-order rate constants for reactions of hydrogen peroxide, acetohydroxamate, and fluoride anions with phosphorylated pyridine monoanions (H20, 25 O C , ionic strength 1.5) are larger than those of "normal" oxygen nucleophiles of the same pK, by factors of 600-, 160-, and 30-fold, respectively. The values of {-&} = 0.70 and 0.86 for reactions of phosphorylated pyridines with hydrogen pe...
متن کاملVarambally , in Cancer Overexpression of Histone Methyltransferase EZH
www.sciencemag.org (this information is current as of January 12, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/322/5908/1695 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1165395/DC1 can be found at...
متن کاملEnzyme-catalyzed phosphoryl transfer reactions.
PERSPECTIVES AND SUMMARY ................... ... ...................................................... 877 Classes of enzyme involving reactions at phosphorus...................................................... 878 COVALENT REACTION INTERMEDIATES, CRYPTIC AND OTHERWISE........................................................................................................ 879 Reactions of Pho...
متن کاملModels for biological phosphoryl transfer.
Quantifying the rate of phosphate monoester dianion hydrolysis under physiological conditions has implications for designing transition state mimics and understanding how catalysis is facilitated. Catalysis is energetically most efficient if the mechanistic pathway in solution is stabilised. Monoesters are believed to have a "dissociative" transition state that has little bonding to the nucleop...
متن کاملA new synthesis of phosphoryl-enolpyruvic acid.
While investigating the enzymatic conversion of n-glyceric acid-3phosphoric acid to pyruvic acid and phosphoric acid, an essential step both in glycolysis and fermentation, Meyerhof and Lohmann (1) observed the formation of a hitherto unknown organic phosphoric acid ester. They succeeded in isolating the new intermediary compound by virtue of the ease of crystallization of the silver-barium sal...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2011
ISSN: 1934-5909
DOI: 10.1016/j.stem.2011.02.012